Ecdysteroid biosynthesis

Q. I read your review of creatine online and found it very informational. I am wondering if you can share some information about the recent body-building supplement Ecdy Bolin. I have been using it for a couple months (both with creatine and also without). It is promoted as has other benefits aside from muscle-building, such as nerve function. Anyway, I would like to know if you feel this supplement is a safe and a quality addition and how you feel about it in general. At the moment, I am not using creatine, only Ecdy Bolin.
   A. An internet search reveals Ecdy Bolin has 100 mg of ecdysterone. I have not seen any human studies with Ecdy Bolin or ecdysterone, so I have no opinion on this supplement at this time.

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The 19S regulatory particle is responsible for stimulating the 20S to degrade proteins. A primary function of the 19S regulatory ATPases is to open the gate in the 20S that blocks the entry of substrates into the degradation chamber. [33] The mechanism by which the proteasomal ATPase open this gate has been recently elucidated. [16] 20S gate opening, and thus substrate degradation, requires the C-termini of the proteasomal ATPases, which contains a specific motif (., HbYX motif). The ATPases C-termini bind into pockets in the top of the 20S, and tether the ATPase complex to the 20S proteolytic complex, thus joining the substrate unfolding equipment with the 20S degradation machinery. Binding of these C-termini into these 20S pockets by themselves stimulates opening of the gate in the 20S in much the same way that a "key-in-a-lock" opens a door. [16] The precise mechanism by which this "key-in-a-lock" mechanism functions has been structurally elucidated. [34]

Ecdysteroid biosynthesis

ecdysteroid biosynthesis

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