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CRH is produced by parvocellular neuroendocrine cells within the paraventricular nucleus of the hypothalamus and is released at the median eminence from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system . The portal system carries the CRH to the anterior lobe of the pituitary , where it stimulates corticotropes to secrete adrenocorticotropic hormone ( ACTH ) and other biologically-active substances ( β-endorphin ). ACTH stimulates the synthesis of cortisol , glucocorticoids , mineralocorticoids and DHEA . [7]

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