Thyroxine and triiodothyronine can be measured as free thyroxine and free triiodothyronine , which are indicators of thyroxine and triiodothyronine activities in the body. They can also be measured as total thyroxine and total triiodothyronine , which also depend on the thyroxine and triiodothyronine that is bound to thyroxine-binding globulin . A related parameter is the free thyroxine index , which is total thyroxine multiplied by thyroid hormone uptake , which, in turn, is a measure of the unbound thyroxine-binding globulins.  Additionally, thyroid disorders can be detected prenatally using advanced imaging techniques and testing fetal hormone levels. 
Radioactive iodine ablation has been safely used for over 50 years, and the only major reasons for not using it are pregnancy and breast-feeding. This form of therapy is the treatment of choice for recurring Graves' disease, patients with severe cardiac involvement, those with multinodular goiter or toxic adenomas, and patients who cannot tolerate antithyroid drugs. Radioactive iodine must be used with caution in patients with Graves' related eye disease since recent studies have shown that the eye disease may worsen after therapy. If a woman chooses to become pregnant after ablation, it is recommended she wait 8-12 months after treatment before conceiving.