What is statin myopathy?
A person with statin myopathy has inflammation of the muscles , caused by a statin medication . The muscle inflammation is a side effect of statin medications , which are used to treat high cholesterol . The most severe form of statin myopathy causes destruction of the muscle tissue, which is called rhabdomyolysis .
What are the symptoms of statin myopathy?
The most common symptoms of statin myopathy include muscle pain and muscle weakness . Additional symptoms of worsening statin myopathy include muscle swelling , and pink, red, or brown urine .
How does the doctor treat statin myopathy?
Treatment for statin myopathy includes stopping the statin medication . Additional treatment for rhabdomyolysis may include intravenous fluids and medications, Treatment for severe rhabdomyolysis may include kidney dialysis .
Proximal myopathy presents as symmetrical weakness of proximal upper and/or lower limbs. There is a broad range of underlying causes including drugs, alcohol, thyroid disease, osteomalacia, idiopathic inflammatory myopathies (IIM), hereditary myopathies, malignancy, infections and sarcoidosis. Clinical assessment should aim to distinguish proximal myopathy from other conditions that can present similarly, identify patients who need prompt attention, like those with cardiac, respiratory or pharyngeal muscle involvement, and determine underlying cause of myopathy. Initial evaluation should include simple tests, like creatine kinase, thyroid function and (25)OH vitamin D levels, but further evaluation including neurophysiological studies, muscle imaging and muscle biopsy should be considered for patients in whom no toxic, metabolic or endocrine cause is found, and in those with clinical features suggestive of inflammatory or hereditary myopathy. Additionally, screening for malignancy and testing for anti-Jo1 antibody is indicated for selected patients with IIM. Management depends on underlying cause, and includes measures, such as removal of offending agent, correction of endocrine or metabolic problem, corticosteroids and immunosuppressive therapy for IIM, and physical therapy, rehabilitation and genetic counselling for muscular dystrophies.