Neuropsychiatric: A wide range of psychiatric reactions including affective disorders (such as irritable, euphoric, depressed and labile mood, and suicidal thoughts), psychotic reactions (including mania, delusions, hallucinations, and aggravation of schizophrenia), marked euphoria leading to dependence; aggravation of epilepsy, behavioural disturbances, irritability, nervousness, anxiety, sleep disturbances, and cognitive dysfunction including confusion and amnesia have been reported. Reactions are common and may occur in both adults and children. In adults, the frequency of severe reactions has been estimated to be 5-6%. Psychological effects have been reported on withdrawal of corticosteroids; the frequency is unknown.
If any of the following serious side effects occur, stop giving Prednisolone and seek emergency veterinary medical attention: an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), increased blood pressure, or sudden weight gain. Other less serious side effects may occur. Continue giving Prednisolone and talk to your veterinarian if your pet experiences insomnia, nausea, vomiting or stomach upset, fatigue, muscle weakness or joint pain, problems with diabetes control, or increased hunger or thirst. Other side effects that occur rarely, usually with high doses of Prednisolone include thinning of the skin, cataracts, glaucoma, or behavior changes. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.