Stereochemistry of steroids pdf

An often cited example of the importance of stereochemistry relates to the thalidomide disaster. Thalidomide is a pharmaceutical drug , first prepared in 1957 in Germany, prescribed for treating morning sickness in pregnant women. The drug was discovered to be teratogenic , causing serious genetic damage to early embryonic growth and development, leading to limb deformation in babies. Some of the several proposed mechanisms of teratogenecity involve a different biological function for the ( R )- and the ( S )-thalidomide enantiomers. [3] In the human body however, thalidomide undergoes racemization : even if only one of the two enantiomers is administered as a drug, the other enantiomer is produced as a result of metabolism. [4] Accordingly, it is incorrect to state that one of the stereoisomer is safe while the other is teratogenic. [5] Thalidomide is currently used for the treatment of other diseases, notably cancer and leprosy . Strict regulations and controls have been enabled to avoid its use by pregnant women and prevent developmental deformations. This disaster was a driving force behind requiring strict testing of drugs before making them available to the public.

Stereochemistry of steroids pdf

stereochemistry of steroids pdf

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