High dosages of oral corticosteroids taken daily for prolonged periods of time can have serious systemic side effects including bone loss ( osteoporosis), increased risk of infections and diabetes and cataracts, thinning of skin, stretch marks, increased facial/body hair growth, acne, fluid retention, weight gain with redistribution of fat (fat deposits on back and face, thinning of limbs), muscle weakness, decreased resistance to infections, stomach ulcers, mood swings, insomnia, suppression of the body's own production of cortisol, etc.
I have had a series of both facet block injections and steroid epidurals with my most recent one in August, 2012. I have degenerative disc/spondylolisthesis at L4/5 diagnosed years ago. I am very fit and worked hard most of my life to eat healthy, exercise at an intense level, and keep my weight in normal range. Facet blocks and steroid epidurals will make you gain weight and even though I've continued to exercise and watch my diet throughout my treatments, I have still gained 10-15 lbs.
Some prescriptions like Lyrica will also make you gain wieght very quickly.