Anabolic steroids differ in their characteristics, which means there are steroids that are only suitable for specific uses. For instance, Trenbolone is not recommended for bulking but it is an outstanding fat burner. This makes it perfect for a lean mass cycle or a cutting cycle. Always take the side effects of a particular compound into consideration whenever you plan a stack. Do not combine anabolic steroids that show similar side effects. For example, never combine Anapolon and Dianabol because they are already quite toxic and if you combine them, the toxicity will increase exponentially and cause serious damage to your body.
I like to use soy phytoestrogens supplements and foods (tofu, soy milk). These block certain cell receptor sites for estradiol. This can help both men and women to reduce problems caused by having too much estrogen. Also, as you lose weight and reduce fat in your diet, your levels of bad estrogen will decline. Your body will have less fat to make more of the bad type of estrogen. It's best to take supplements of natural steroid hormones (testosterone, progesterone, estrogen, pregnenolone, DHEA) in the morning. All hormones peak at 4-5 hours after ingestion, then, within 24 hours, the levels come back down.
P450scc is always active, however its activity is limited by the supply of cholesterol in the inner membrane. The supplying of cholesterol to this membrane (from the outer mitochondrial membrane ) is, thus, considered the true rate-limiting step in steroid production. This step is mediated primarily by the steroidogenic acute regulatory protein (StAR or STARD1). Upon stimulation of a cell to make steroid, the amount of StAR available to transfer cholesterol to the inner membrane limits how fast the reaction can go (the acute phase). With prolonged (chronic) stimulation, it is thought that cholesterol supply becomes no longer an issue and that the capacity of the system to make steroid (., level of P450scc in the mitochondria) is now more important.