Prednisone is a drug that belongs to the corticosteroid drug class, and is an
anti-inflammatory and immune system suppressant. It's used to treat a variety of diseases and conditions, for example: inflammatory bowel disease (Crohn's
disease and ulcerative colitis), lupus, asthma, cancers, and several types of
Common side effects are weight gain, headache, fluid retention, and muscle weakness. Other effects and adverse events include glaucoma, cataracts, obesity, facial hair growth, moon face, and growth retardation in children. This medicine also causes psychiatric problems, for example: depression, insomnia, mood swings, personality changes, and psychotic behavior. Serious side effects include reactions to diabetes drugs, infections, and necrosis of the hips and joints.
Corticosteroids like prednisone, have many drug interactions; examples include: estrogens, phenytoin (Dilantin), diuretics, warfarin (Coumadin, Jantoven), and diabetes drugs. Prednisone is available as tablets of 1, , 10, 20, and 50 mg; extended release tablets of 1, 2, and 5mg; and oral solution of 5mg/5ml. It's use during the first trimester of pregnancy may cause cleft palate. This medicine is secreted in breast milk and can cause side effects in infants who are nursing. You should not stop taking prednisone abruptly because it can cause withdrawal symptoms and adrenal failure. Talk with your doctor, pharmacist, or other medical professional if you have questions about beta-blockers. Talk with your doctor, pharmacist, or other medical professional if you have questions about prednisone.
If you notice other effects not listed above, contact your doctor or pharmacist. In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
In a traditional view, the endocrine action of steroid hormones is based on the concept where the hormone is synthesized in the gland and reaches the target organ via blood circulation. Our group has been actively involved in studies providing evidence for the concept of “intracrinology”, where the ligand concentration available for nuclear receptor is regulated also by the target tissue metabolism. Especially, we study the role of HSD17B enzymes in the steroid and lipid metabolism by applying genetically modified mouse models, tumor xenografts and by using clinical specimens. Current topics include: 1) To define the role of HSD17B enzymes in regulating the amount and type of ligand for nuclear receptor action, 2) To define the role of local sex steroid synthesis in the etiopathogenesis of breast and prostate cancer, and 3) To define the role of intra tissue sex steroid synthesis and steroid hormone action in endometrium and the role of the enzymes in etiopathogenesis of endometriosis. Of the research techniques we have devoted to efficient production of various genetically modified mouse models, to generate novel statistical methods for studies in vivo, and to set-up novel methods for steroid analyses using mass spectrometric methods.