Steroid hormone implants

A larger study with longer follow-up concluded that "use of DMPA during pregnancy or breastfeeding does not adversely affect the long-term growth and development of children". This study also noted that "children with DMPA exposure during pregnancy and lactation had an increased risk of suboptimal growth in height," but that "after adjustment for socioeconomic factors by multiple logistic regression, there was no increased risk of impaired growth among the DMPA-exposed children." The study also noted that effects of DMPA exposure on puberty require further study, as so few children over the age of 10 were observed. [85]

BRCA1 and BRCA2 mutations confer a high risk of breast cancer in carriers (high-penetrance). Women with a BRCA1 or BRCA2 mutation have a 45-65% chance of developing breast cancer by age 70.[ 7 ] BRCA1/2 mutation-carriers have higher breast cancer risk compared with the general population in all age groups.[ 1 ] BRCA2-negative women with a BRCA2-carrying first-degree relative may also have increased breast cancer risk, a small UK cohort study showed.[ 8 ] Higher sex hormone levels in BRCA mutation carriers may explain some of the increased risk.[ 9 ]

Steroid hormone implants

steroid hormone implants


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